![]() When we take the results further, we’re seeing that no matter where that patient is coming from, if that patient is treatment naïve, if that patient was on aflibercept, ranibizumab, or another agent, their anatomy is going to improve, so their central subfield thickness is going to go down. That therapeutic effect is augmented after 3 injections, when we see a further improvement up to 3.2 letters in their best-corrected visual acuity and a further decrease or improvement in their central subfield thickness of almost 50 μm on their OCT. ![]() When we look at patients, including patients who bad disease previously and were switched over to faricimab after 1 injection, we see an improvement of about 1.1 letters, with a nice improvement of over 30 μm on the central subfield thickness OCT. Then they’ll use something similar to what longer-term use is going to model, which is multiple injections, namely 3 in the TRUCKEE study. They may use 1 injection and then assess what the response is like. ![]() One, what happens when you have a patient who has 1 injection? A lot of retina specialists, a lot of investigators, are going to use that medicine that’s been approved, but they may not necessarily sign up for multiple dose regimens or continuous use of that medication. We’re going to look at 2 scenarios in TRUCKEE. Treatment-naïve patients in TRUCKEE were about 10%, which is a much smaller portion compared with the registry trials but still represented in the TRUCKEE sample. Brolucizumab and bevacizumab, were less than 10%. There was also ranibizumab, which is about 10%. Of that group, aflibercept was over 50% of patients who were switched from aflibercept to faricimab. Do these patients have previous treatment? This is the largest group, 90% of patients in TRUCKEE. The group could be defined in large silos. We looked at durability: how long do the patients go after these injections? We also looked at safety: are there any new safety signals that we need to worry about? When we move to the results of TRUCKEE, we look at a well-balanced population of over 500 patients. Anatomical outcomes like central subfield thickness, degree of pigment epithelial detachment, or choroidal neovascular membrane. The main outcome measure that we were looking at is best-corrected visual acuity, which is ultimately what the patient cares about the most. But it’s going to take all comers, essentially treatment-naïve patients, patients who are switched from another medicine, and patients who have been on multiple medicines and are switched and moved to intravitreal faricimab. This is where TRUCKEE comes in, because it’s essentially a real-world prospective study that evaluates the safety and efficacy of faricimab. A large part, especially at the beginning, tend to be recalcitrant patients with multiple treatment regimens in the past. That means that real-world patients tend not to be treatment naïve or. Biphasic compounds in the real world don’t always get used the way clinical trials are modeled out. The drive and impetus for TRUCKEE was the idea that medications like faricimab, which is a biphasic compound, can address both VEGF-A and Ang2 as targets. 1 cause of blindness in patients over 65, so it was a logical starting point. Age-related macular degeneration is the No. I had the pleasure of being at the Congress on Controversies in Ophthalmology in Lisbon, Portugal, at the end of March, where I presented my poster on the TRUCKEE study, a real-world efficacy and safety of faricimab and neovascular age-related macular degeneration. I’m a retina specialist and the director of clinical research at Erie Retinal Surgery in Erie, Pennsylvania. David Almeida, MD, PhD, MBA: My name is Dr David Almeida. Now all of a sudden it Only shows up in a totally different state and with exact name search. ![]() Is there something I could do to send signals to Google to show that I am in Matthews, NC?Ģ months ago my listing quit showing up at all unless you typed exact business name What could possibly cause my listing or Google to do this? I have been without my listing for a few months now and have NO calls coming in from it. If you search Locksmith Independence, KS it shows up on the maps. If you search Locksmith Matthews, NC my listing does not show up at all. Keep in mind the GMB is in Matthews, NC All my service areas and the actual map show the correct areas. Now if I search my business name under the auto populate I see it with Independence, KS on the listing. I pretty much do not have any traffic, views or calls now. Posted about my SAB listing a few weeks ago about not showing up in search only when you entered the exact name. ![]()
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